Do I need a Cancer Antigen 125 test?

Are you concerned about ovarian health, or wondering what's behind symptoms like persistent pelvic discomfort? Cancer Antigen 125 (CA-125) is a biomarker that can help you understand what's happening in your body.

CA-125 measures a protein found on ovarian cancer cells that's released into your bloodstream. While it's most commonly associated with ovarian cancer, mild elevations may also occur with endometriosis, menstruation, uterine fibroids, or pelvic infections.

Understanding your CA-125 levels can be valuable for monitoring ovarian health over time and supporting conversations with your doctor. This biomarker is part of Listen Health's cancer indicator panel, giving you insight into your body's patterns and helping you make informed decisions about your wellbeing.

Cancer Antigen 125 — Key Facts
MeasuresUsed primarily to monitor ovarian function and detect ovarian cancer or pelvic inflammatory conditions.
CategoryCancer Indicators
Unitpositive / negative
Tested inListen Health Standard & Premium membership (100+ biomarkers)
Reviewed byDr Jamie Deans, MBChB

What is it?

CA-125 is a protein found on the surface of many ovarian cancer cells and released into the bloodstream. While it’s most often associated with ovarian cancer, mild elevations can also occur in endometriosis, menstruation, uterine fibroids, or pelvic infections.

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Why does it matter?

CA-125 is a valuable monitoring tool for ovarian cancer — not a standalone screening test. It helps:

  • Track response to treatment and detect recurrence.

  • Support diagnosis when combined with imaging (e.g., pelvic ultrasound) and clinical findings.

High CA-125 doesn’t always mean cancer, but consistently elevated levels or rising trends warrant further investigation.


Frequently Asked Questions

AHPRA Disclaimer: This information is general in nature and should not replace individual medical advice. Always discuss your test results and health concerns with a registered healthcare practitioner.